{
  "slug": "undetectable-proviral-dna-and-viral-rna-levels-after-raltegrav-36324639",
  "source": {
    "title": "Undetectable proviral DNA and viral RNA levels after raltegravir administration in two cats with natural feline leukemia virus infection.",
    "journal": "Brazilian journal of veterinary medicine",
    "year": 2022,
    "doi": "10.29374/2527-2179.bjvm003522",
    "pmid": "36324639",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "Case two had undetectable viral RNA before raltegravir administration despite detectable proviral DNA.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "However, when quantitative PCR was performed for both RNA and proviral DNA loads, the former was undetectable and the latter was positive (3.3 x10 4 proviral DNA copies/mL of whole blood).",
      "review_status": "PASSED"
    },
    {
      "statement": "The authors identify the small number of cats and insufficient follow-up for evaluating long-term monotherapy efficiency as limitations.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Despite the absence of adverse effects and the outcomes of both current patients, this report was limited due to the number of cats. Moreover, there is a concern over long-term monotherapy efficiency, which was not evaluated due to the short follow-up time.",
      "review_status": "PASSED"
    },
    {
      "statement": "The observed virological and clinical changes cannot be confidently attributed to raltegravir rather than the natural course of infection and concurrent care.",
      "epistemic_type": "INFERENCE",
      "evidence_level": null,
      "confidence": "95",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-PHARMA-005",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}