{
  "slug": "tracing-feline-herpesvirus-1-exposure-in-domestic-cats-from-na-42554915",
  "source": {
    "title": "Tracing feline herpesvirus-1 exposure in domestic cats from Namibia: associations with neutralising antibodies, vaccination, clinical signs, and retroviral status.",
    "journal": "Veterinary research communications",
    "year": 2026,
    "doi": "10.1007/s11259-026-11446-3",
    "pmid": "42554915",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The study's subgroup analyses were limited by only 18 seropositive cats and 23 cats with a recorded vaccination history; multivariable regression and multiple-comparison adjustment were not performed.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Multivariable logistic regression was not considered sufficiently powered and no adjustment for multiple comparisons was applied, because only 18 cats were seropositive and only 23 cats had a recorded vaccination history.",
      "review_status": "PASSED"
    },
    {
      "statement": "Some vaccinated cats without detectable FHV-1 neutralising antibodies were FeLV antigen-positive, an observation explicitly described as exploratory.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "An exploratory observation in the present study was that a proportion of vaccinated cats lacking detectable neutralising antibodies were FeLV antigen-positive.",
      "review_status": "PASSED"
    },
    {
      "statement": "The study did not independently re-test FeLV status, and the authors could not exclude misclassification from previously reported antigen testing.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Since FeLV status was derived from previously reported antigen testing (De Villiers et al. 2025 ) and not independently re-tested in the present analysis, possible misclassification cannot be fully excluded.",
      "review_status": "PASSED"
    },
    {
      "statement": "FHV-1 seropositivity was not significantly associated with FeLV antigen status in this cohort (OR = 0.40; 95% CI: 0.13–1.25).",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Likewise, no associations were detected between seropositivity and FIV antibody positivity (OR = 1.37; 95% CI: 0.16–11.43) or FeLV antigen status (OR = 0.40; 95% CI: 0.13–1.25) (Table 3 ).",
      "review_status": "PASSED"
    },
    {
      "statement": "Whether FeLV-related impairment of humoral immunity explains absent detectable FHV-1 neutralising antibodies in vaccinated FeLV-positive cats remains an open question.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "99",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-IMMUNOLOGY-002",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:30Z"
  }
}