{
  "slug": "the-use-of-selected-electrophoretic-techniques-to-assess-the-h-41497461",
  "source": {
    "title": "The use of selected electrophoretic techniques to assess the health of domestic cats (Felis catus).",
    "journal": "Journal of veterinary research",
    "year": 2025,
    "doi": "10.2478/jvetres-2025-0062",
    "pmid": "41497461",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "FeLV-test-positive cat No. 1 had reduced serum albumin and elevated alpha- and beta-globulin concentrations, while its gamma-globulin concentration was within the listed reference range.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Table 2. Concentrations of individual protein fractions in serum protein electrophoresis – cat No. 1 Fraction Relative area (%) Concentration (g/L) Range (g/L) Albumin-to-globulin ratio Albumins 29.93 20.06↓ 27–39 α-globulins 30.96 20.74↑ 6.5–12.1 β-globulins 19.72 13.21↑ 4.5–8.7 γ-globulins 19.39 12.99 10.0–18.6 Total protein 67 60–80 A/G ratio 0.43",
      "review_status": "PASSED"
    },
    {
      "statement": "FeLV antigen was detected in two cats in the group undergoing detailed investigation after abnormal electropherograms.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "The results of the plate tests for viral infections were as follows: FIV antibodies were detected in two cats, FeLV antigen was detected in two cats and FIP antibodies were also detected in two cats.",
      "review_status": "PASSED"
    },
    {
      "statement": "The comet-assay comparison included 25 cats with abnormal serum protein electropherograms and 25 cats without electropherogram abnormalities that were clinically assessed as healthy.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Twenty-five cats for which native serum protein electrophoresis revealed clear abnormalities were selected for the comet assay. In addition, a comparative analysis was performed using the assay on 25 cats without abnormalities in their electropherograms. These cats were clinically assessed as healthy.",
      "review_status": "PASSED"
    },
    {
      "statement": "Protein fraction disturbances and unexplained blood-count changes were also observed in clinically well cats that tested negative for the infectious diseases examined.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "It should be noted that individuals with overall condition assessed as good and which tested negative for infectious diseases also had protein fraction disturbances and unexplained changes in their blood counts.",
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-IMMUNOLOGY-002",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:30Z"
  }
}