{
  "slug": "the-role-of-homologous-recombination-in-human-retrovirus-assoc-41420694",
  "source": {
    "title": "The role of homologous recombination in human retrovirus-associated diseases.",
    "journal": "Virus genes",
    "year": 2026,
    "doi": "10.1007/s11262-025-02210-x",
    "pmid": "41420694",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The review reports that HTLV-1 p30 suppresses homologous recombination and shifts double-strand break repair toward non-homologous end joining.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "Collectively, in HIV-1, RAD51 is upregulated and can support LTR transcription, whereas in HTLV-1, p30 suppresses HR and shifts double-strand break repair toward the non-homologous end-joining pathway.",
      "review_status": "PASSED"
    },
    {
      "statement": "The review reports that stimulation of RAD51 nucleofilament formation can restrict HIV-1 integration.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "stimulation of RAD51 nucleofilament formation can restrict HIV-1 integration, highlighting its dual role as both a facilitator and a potential restriction factor.",
      "review_status": "PASSED"
    },
    {
      "statement": "The review reports that RAD51 can support HIV-1 LTR transcription.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "Collectively, in HIV-1, RAD51 is upregulated and can support LTR transcription, whereas in HTLV-1, p30 suppresses HR and shifts double-strand break repair toward the non-homologous end-joining pathway.",
      "review_status": "PASSED"
    },
    {
      "statement": "Whether elevated RAD51 in ATLL reflects an ineffective compensatory response to DNA damage or supports survival of genetically unstable cells remains an open question.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-VIROLOGY-001",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}