{
  "slug": "rapidly-progressive-and-relapsing-myelitis-with-human-t-lympho-41894649",
  "source": {
    "title": "Rapidly Progressive and Relapsing Myelitis With Human T Lymphotropic Virus Type 1: A Case Report and Review of the Literature.",
    "journal": "Neurology(R) neuroimmunology & neuroinflammation",
    "year": 2026,
    "doi": "10.1212/nxi.0000000000200570",
    "pmid": "41894649",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "Reported testing for AQP4 and MOG IgG was absent in cases published before 2009 and incomplete among subsequently published cases.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "No cases published before 2009 (21 total) reported testing for AQP4 or MOG IgG, and of the remaining 24 cases, 12 (50%) reported testing for AQP4 IgG and 7 (29%) tested MOG IgG.",
      "review_status": "PASSED"
    },
    {
      "statement": "In the reviewed human cases, the RESULTS section reports radiographic myelitis in 98%, longitudinally extensive myelitis in 91%, and focal myelitis in 7%.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "Most patients had radiographic features of myelitis (98%), with 91% showing a longitudinally extensive myelitis and 7% showing focal myelitis.",
      "review_status": "PASSED"
    },
    {
      "statement": "The review pooled the index patient's data with systematically collected published cases of rapidly progressive or relapsing HTLV-1-associated myelitis that included spinal imaging.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "To supplement the literature review, her data were pooled along with systematically collected clinical, diagnostic, and treatment data from published cases of rapidly progressive or relapsing myelitis associated with HTLV-1 that included spine imaging during diagnostic evaluation.",
      "review_status": "PASSED"
    },
    {
      "statement": "Whether the reported short-term changes correspond to altered chronic disease progression remains unresolved.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "99",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-VIROLOGY-001",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:30Z"
  }
}