{
  "slug": "prospective-investigation-of-feline-leukemia-virus-infection-i-38543760",
  "source": {
    "title": "Prospective Investigation of Feline Leukemia Virus Infection in Stray Cats Subjected to a Trap-Neuter-Return Program in Switzerland.",
    "journal": "Viruses",
    "year": 2024,
    "doi": "10.3390/v16030394",
    "pmid": "38543760",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The observed FeLV sample prevalence among 1711 stray cats was 4.0% (95% CI 3.1–5.0%).",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Overall, the FeLV prevalence in the 1711 stray cats was 4.0% (95% CI 3.1–5.0%).",
      "review_status": "PASSED"
    },
    {
      "statement": "The diagnostic approach does not uniquely identify progressive infection because some early regressive infections can also be antigenemic or salivary RNA positive.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "99",
      "evidence_excerpt": "Both methods primarily identify cats with a progressive infection, but they also identify a part of the regressively infected cats in the very early phase of the infection when these cats can also be antigenemic/salivary viral RNA positive.",
      "review_status": "PASSED"
    },
    {
      "statement": "The study could not detect provirus-positive, antigen-negative regressive FeLV infections because blood samples were unavailable for provirus qPCR.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Due to the unavailability of blood samples, we could not test for FeLV provirus with qPCR. Consequently, stray cats with a regressive FeLV infection, provirus PCR positive but antigen negative [ 7 , 8 ], were not detected in the current study.",
      "review_status": "PASSED"
    },
    {
      "statement": "Clinical signs were not investigated systematically, and their reporting depended on the attending veterinarian.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "However, it was not the goal of the present study to investigate clinical signs in the sampled cats, and thus, the study setup was not designed for this. Clinical signs were only occasionally reported and not according to an exact protocol; thus, the reported data largely depended on the attending veterinarian.",
      "review_status": "PASSED"
    },
    {
      "statement": "The study used prospective opportunistic sampling of stray cats participating in a trap–neuter–return program.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "This prospective study employed opportunistic sampling. We included saliva samples collected from cats subjected to a trap–neuter–return program (NetAP, Esslingen, Switzerland).",
      "review_status": "PASSED"
    },
    {
      "statement": "The reported infection prevalence cannot establish the incidence of FeLV-associated lymphoma or leukemia in this population.",
      "epistemic_type": "INFERENCE",
      "evidence_level": null,
      "confidence": "99",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:30Z"
  }
}