{
  "slug": "prevalence-of-feline-leukemia-virus-infection-and-associated-d-41505408",
  "source": {
    "title": "Prevalence of feline leukemia virus infection and associated diseases in a Portuguese domestic cat population: A 4.5-year cross-sectional study.",
    "journal": "PloS one",
    "year": 2026,
    "doi": "10.1371/journal.pone.0339172",
    "pmid": "41505408",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The authors identify one-off testing without longitudinal retesting for most cats as the study's primary limitation.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "The primary limitation of the present study was that the data were based on a one-off test; most of the cats were not retested over time.",
      "review_status": "PASSED"
    },
    {
      "statement": "Proviral load quantification was mainly performed in sick cats with FeLV-related diseases rather than as a general screening method.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "The high prevalence values for both courses, with more cats categorized in the progressive course, may be attributed to the fact that proviral load quantification was mainly performed in sick cats, with FeLV-related diseases and not as a general screening method.",
      "review_status": "PASSED"
    },
    {
      "statement": "Whether insertional interactions between FeLV proviral DNA and cellular proto-oncogenes contribute to neoplasia in regressively infected cats remains unresolved in the source.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}