{
  "slug": "prevalence-of-different-courses-of-feline-leukaemia-virus-infe-37632060",
  "source": {
    "title": "Prevalence of Different Courses of Feline Leukaemia Virus Infection in Four European Countries.",
    "journal": "Viruses",
    "year": 2023,
    "doi": "10.3390/v15081718",
    "pmid": "37632060",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "Among cats classified as progressively infected, blood p27 antigen concentration was positively correlated with viral RNA load in saliva.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "In cats with progressive infection, a strong significant correlation was observed between the p27 antigen concentration and viral RNA load in saliva (Spearman correlation = 0.65; p < 0.001) ( Figure 3 A).",
      "review_status": "PASSED"
    },
    {
      "statement": "Cats classified as progressively infected had significantly higher proviral copy numbers than cats classified as regressively infected, although their reported ranges overlapped.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Cats with progressive infection had significantly higher copy numbers (median: 21,543, range: 43–9,501,447) compared to cats with regressive infection (median: 1, range: 1–428) ( p < 0.001).",
      "review_status": "PASSED"
    },
    {
      "statement": "The study operationally defined regressive FeLV infection as p27 antigen-negative but provirus-positive.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "(2) regressive infection (p27 antigen-negative, provirus-positive)",
      "review_status": "PASSED"
    },
    {
      "statement": "Single-date sampling prevented the study from determining long-term FeLV infection courses.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Since all cats were only sampled on a single date, no statement can be made about the long-term course. Therefore, the most important limitation of the present study was that the FeLV status was determined only based on one blood sample.",
      "review_status": "PASSED"
    },
    {
      "statement": "The reasons for the different distributions of FeLV infection courses between the sampled countries remain unknown.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-VIROLOGY-001",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}