{
  "slug": "multimodal-imaging-of-hypoxia-metabolism-and-ph-in-feline-sarc-42801581",
  "source": {
    "title": "Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized <sup>13</sup>C MRI and PET.",
    "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
    "year": 2026,
    "doi": "10.1002/advs.77830",
    "pmid": "42801581",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "In this exploratory feline tumor cohort, measured tumor pH was lower than healthy muscle pH within the same animals.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "In addition, a comparison of tumor pH to healthy tissue pH from the same animals also revealed tumor acidification (pH 7.30 ± 0.18) compared to muscle pH (paired t ‐test, pH 7.41 ± 0.11, p = 0.001, Figure 3D ).",
      "review_status": "PASSED"
    },
    {
      "statement": "The imaging data showed a trend toward greater acidification with higher fibrosarcoma grade.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Here, FSs of different grades can show acidification of up to 0.5 pH units (Figure 3E ), with a trend to higher acidification for higher FS grade.",
      "review_status": "PASSED"
    },
    {
      "statement": "No stage of this exploratory pilot study was blinded.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "No blinding was applied at any stage because of the explorative nature of this pilot study.",
      "review_status": "PASSED"
    },
    {
      "statement": "The reported pH measurement averages detected pH compartments using their spectral peak intensities as weights when a voxel contains multiple compartments.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "For voxels containing more than one pH compartment, mean pH values, only reported as pH throughout this study, were averaged using the peak intensities as weights.",
      "review_status": "PASSED"
    },
    {
      "statement": "Extending this sarcoma imaging workflow to FeLV-associated lymphoma or leukemia would require separate validation.",
      "epistemic_type": "INFERENCE",
      "evidence_level": null,
      "confidence": "95",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}