{
  "slug": "long-term-surveillance-of-the-feline-leukemia-virus-in-the-end-38443503",
  "source": {
    "title": "Long-term surveillance of the feline leukemia virus in the endangered Iberian lynx (Lynx pardinus) in Andalusia, Spain (2008-2021).",
    "journal": "Scientific reports",
    "year": 2024,
    "doi": "10.1038/s41598-024-55847-3",
    "pmid": "38443503",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The authors suggest that lynxes may control FeLV infection within bone marrow and other lymphoid tissues, while acknowledging that viral strain and infectious dose were not investigated.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "Without considering FeLV strain and/or infectious dose, both of which we could not investigate, our results suggest that lynxes may therefore control the infection within the bone marrow and other lymphoid tissues, limiting viremia and decreasing the possibility of developing a more aggressive disease due to progressive FeLV infection.",
      "review_status": "PASSED"
    },
    {
      "statement": "Among FeLV provirus-positive lynxes followed from the 2007 outbreak, reported causes of death included squamous cell carcinoma, while most deaths were attributed to bone marrow aplasia.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "The cause of death for FeLV provirus positive individuals varied from road-killed to squamous cell carcinoma, though most deaths were attributed to bone marrow aplasia.",
      "review_status": "PASSED"
    },
    {
      "statement": "The antigenemic lynx described in the fatal clinical case had severe bone marrow aplasia, Streptococcus septicemia, and necrosis in the kidneys and spleen at necropsy.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "The necropsy showed signs of severe bone marrow aplasia, septicemia by Streptococcus sp . and necrosis in kidneys and spleen.",
      "review_status": "PASSED"
    },
    {
      "statement": "During 2008–2021, FeLV proviral DNA was detected more frequently than p27 antigen in the surveyed Iberian lynx population.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "During 2008–2021, the overall prevalence of (1) FeLV p27 antigen in blood, (2) FeLV provirus in blood and (3) FeLV provirus in tissues were 1.4% (± standard error SE 0.62, CI: 0.2–2.6), 6.2% (SE: ± 1.07, CI: 4.1–8.3), and 10.2% (± 1.66, 7.0–13.5), respectively (Table 1 ).",
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}