{
  "slug": "infectious-causes-of-neoplasia-in-the-domestic-cat-36136683",
  "source": {
    "title": "Infectious Causes of Neoplasia in the Domestic Cat.",
    "journal": "Veterinary sciences",
    "year": 2022,
    "doi": "10.3390/vetsci9090467",
    "pmid": "36136683",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The review reports discordant findings on provirus detection in lymphomas from antigen-negative cats.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "However, when investigators have looked for provirus to investigate the outcomes in regressive FeLV infection, there are discordant results; some have suggested this is rare [ 72 , 73 , 74 ], whilst others have suggested as many as 20-60% of lymphomas from antigen-negative cats are provirus positive [ 75 , 76 , 77 ].",
      "review_status": "PASSED"
    },
    {
      "statement": "The review identifies c-myc, flvi-1, flvi-2, fit-1, pim-1, and flit-1 as common integration loci associated with FeLV-associated lymphoma.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "To date, common integration sites (CISs) for the development of FeLV-associated lymphoma have been identified in six loci, namely: c-myc, flvi-1, flvi-2, fit-1, pim-1 , and flit-1 [ 57 , 58 , 62 , 63 , 64 , 65 ].",
      "review_status": "PASSED"
    },
    {
      "statement": "The potential protective role of enFeLV in oncogenesis remains incompletely understood.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    },
    {
      "statement": "The mechanisms by which FeLV LTRs influence mutagenesis remain incompletely understood.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}