{
  "slug": "gamma-retrovirus-integration-marks-cell-type-specific-cancer-g-27097319",
  "source": {
    "title": "Gamma-Retrovirus Integration Marks Cell Type-Specific Cancer Genes: A Novel Profiling Tool in Cancer Genomics.",
    "journal": "PloS one",
    "year": 2016,
    "doi": "10.1371/journal.pone.0154070",
    "pmid": "27097319",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The most prominent FeLV integration targets showed little overlap with the most abundantly expressed transcripts but were strongly enriched for annotated cancer genes.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "The most prominent FeLV integration targets had little overlap with the most abundantly expressed transcripts, but were strongly enriched for annotated cancer genes.",
      "review_status": "PASSED"
    },
    {
      "statement": "FeLV insertion sites in human MCF-7 mammary carcinoma cells showed a strong bias towards active chromatin marks, with no evidence of significant post-integration growth selection.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "Analysis of FeLV insertion sites in the MCF-7 mammary carcinoma cell line revealed strong bias towards active chromatin marks with no evidence of significant post-integration growth selection.",
      "review_status": "PASSED"
    },
    {
      "statement": "A meta-analysis of gamma-retrovirus integration profiling studies in human CD34+, K562 and HepG2 cells reported cancer gene bias and cell-type specificity, with a shared integration hotspot at MALAT1.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "A meta-analysis based on several gamma-retrovirus integration profiling (GRIP) studies in human cells (CD34+, K562, HepG2) revealed a similar cancer gene bias but also remarkable cell-type specificity, with prominent exceptions including a universal integration hotspot at the long non-coding RNA MALAT1.",
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-VIROLOGY-001",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "gpt-6.1-sol",
    "updated": "2026-11-02 11:20 UTC",
    "updated_iso": "2026-11-02T11:20:25Z"
  }
}