{
  "slug": "felix-is-a-restriction-factor-for-mammalian-retrovirus-infecti-38440982",
  "source": {
    "title": "FeLIX is a restriction factor for mammalian retrovirus infection.",
    "journal": "Journal of virology",
    "year": 2024,
    "doi": "10.1128/jvi.01771-23",
    "pmid": "38440982",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "Soluble truncated Env proteins derived from enFeLV inhibited enFeLV and FeLV-B infection in the reported laboratory experiments.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "B",
      "confidence": "98",
      "evidence_excerpt": "When soluble truncated Env proteins from enFeLV were tested for their inhibitory effects against enFeLV and FeLV-B, they inhibited viral infection.",
      "review_status": "PASSED"
    },
    {
      "statement": "The tested infectious enFeLV Env pseudotypes infected mouse-derived MDTF cells expressing feline Pit1 but did not infect MDTF cells expressing feline Pit2.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "99",
      "evidence_excerpt": "The results showed that MDTF-fePit1 cells were permissive to enFeLV Env-pseudotyped virus infection of clone1 E345G, clone2, clone3, and AGTT, whereas MDTF-fePit2 cells were not infected with any of the enFeLV Env-pseudotyped viruses ( Fig. 2D ).",
      "review_status": "PASSED"
    },
    {
      "statement": "The integration-time analysis substituted a domestic cat noncoding-region divergence rate for an unknown enFeLV LTR mutation rate.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "E",
      "confidence": "100",
      "evidence_excerpt": "The mean divergence rate of noncoding regions in the domestic cat genome (1.2 × 10 −8 substitutions/site/year) was used because the mutation rate of LTRs in enFeLVs is unknown ( 80 ).",
      "review_status": "PASSED"
    },
    {
      "statement": "The exact in vivo roles of the soluble enFeLV-derived Env proteins remain unresolved.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-VIROLOGY-001",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:30Z"
  }
}