{
  "slug": "feline-paraneoplastic-hypereosinophilic-syndrome-associated-wi-42422439",
  "source": {
    "title": "Feline paraneoplastic hypereosinophilic syndrome associated with lymphocytic intestinal lymphoma.",
    "journal": "Brazilian journal of veterinary medicine",
    "year": 2026,
    "doi": "10.29374/2527-2179.bjvm000926",
    "pmid": "42422439",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The reported lymphoma case involved a 13-year-old neutered male Persian cat described as negative for FIV and FeLV.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "A 13-year-old neutered male Persian cat, negative for FIV and FeLV, was presented with a four-month history of frequent vomiting.",
      "review_status": "PASSED"
    },
    {
      "statement": "Histopathological examination of duodenal, jejunal, and mesenteric lymph node biopsies confirmed feline lymphocytic alimentary lymphoma.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "After the results, it was decided to perform a biopsy of the duodenum, jejunum, and mesenteric lymph node, in which the histopathological examination confirmed the diagnosis of feline lymphocytic alimentary lymphoma.",
      "review_status": "PASSED"
    },
    {
      "statement": "Repeat hematology documented 81,500 leukocytes/µL and 69,000 eosinophils/µL, with no immature peripheral eosinophils observed.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "On repeat examination, leukocyte counts doubled to 81,500 leukocytes/µL, with a marked increase in absolute eosinophil count (69,000/µL). All eosinophils were segmented, with no immature forms observed.",
      "review_status": "PASSED"
    },
    {
      "statement": "The bone marrow profile was consistent with reactive eosinophilic hyperplasia, but cytomorphology alone could not exclude chronic eosinophilic leukemia.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "This profile is consistent with reactive (secondary) eosinophilic hyperplasia; however, a primary clonal disorder, such as chronic eosinophilic leukemia, cannot be excluded based solely on cytomorphological criteria.",
      "review_status": "PASSED"
    },
    {
      "statement": "The exact pathophysiology of lymphoma-associated hypereosinophilia in cats remains poorly understood.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:30Z"
  }
}