{
  "slug": "feline-lymphoma-in-focus-examining-the-patterns-and-types-in-c-41150128",
  "source": {
    "title": "Feline Lymphoma in Focus: Examining the Patterns and Types in Croatia's Pathological Records.",
    "journal": "Veterinary sciences",
    "year": 2025,
    "doi": "10.3390/vetsci12100986",
    "pmid": "41150128",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The reported immunophenotype distribution varied by anatomical site, with mediastinal lymphoma almost exclusively T-cell and alimentary lymphoma predominantly B-cell.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "In our data, the distribution of B- versus T-cell lymphoma depended strongly on anatomical type: mediastinal lymphomas were almost exclusively T-cell, whereas alimentary lymphomas were predominantly B-cell ( Table 3 ).",
      "review_status": "PASSED"
    },
    {
      "statement": "Among 128 lymphoma cases with anatomical classification, multicentric, alimentary and mediastinal forms accounted for 27.3%, 26.6% and 25%, respectively.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Anatomical classification was available for 128 (68.1%) of the lymphoma cases. Among these, multicentric lymphoma was the most common subtype (35, 27.3%), followed by alimentary (34, 26.6%), mediastinal (32, 25%), and extranodal lymphomas (27, 21.1%).",
      "review_status": "PASSED"
    },
    {
      "statement": "FeLV/FIV testing preferentially involved younger cats with mediastinal lymphoma, limiting the generalizability of the reported viral associations.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "We should note that FeLV/FIV testing in our study was performed mainly in younger cats, most of which had mediastinal lymphoma. This biased testing pattern likely explains the high apparent prevalence and limits the generalizability of FeLV/FIV associations to the broader population.",
      "review_status": "PASSED"
    },
    {
      "statement": "The authors report an association between FeLV infection and mediastinal lymphoma, with nearly 70% of FeLV-positive cats classified as having mediastinal disease.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "98",
      "evidence_excerpt": "Among lymphoma cases, 32 cats (75% of those tested for FeLV/FIV) were positive for these viruses, representing 17% of all lymphoma cases in the study, with a strong association between FeLV infection and mediastinal lymphoma, as nearly 70% of FeLV-positive cats fell into this category followed by multicentric lymphoma.",
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "gpt-6.1-sol",
    "updated": "2026-11-02 11:20 UTC",
    "updated_iso": "2026-11-02T11:20:26Z"
  }
}