{
  "slug": "feline-leukemia-virus-lifetime-study-whole-blood-samples-incre-41215536",
  "source": {
    "title": "Feline leukemia virus lifetime study: whole blood samples increase detection of low positive cats with extended long-term survival.",
    "journal": "Journal of feline medicine and surgery",
    "year": 2025,
    "doi": "10.1177/1098612x251379219",
    "pmid": "41215536",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "In low positive cats, SNAP detected FeLV p27 antigen more frequently in whole blood than in plasma or serum at enrollment.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Whole blood detected 28/29 (97%, 95% CI 83–99), plasma detected 23/29 (79%, 95% CI 62–90) and serum detected 19/29 (66%, 95% CI 47–80), suggesting that whole blood was significantly more sensitive than serum.",
      "review_status": "PASSED"
    },
    {
      "statement": "Restricted peripheral-blood sampling left potential focal infection in bone marrow or lymphoid tissue uncharacterized.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "99",
      "evidence_excerpt": "A limitation of this study was that sampling was restricted to the minimally invasive collection of peripheral blood for FeLV testing. More invasive sampling of tissues such as bone marrow or lymphoid tissue may have revealed virus harbored in focal infections or the source of antigen or provirus found in circulation.",
      "review_status": "PASSED"
    },
    {
      "statement": "High positive cats had lower survival probability than low positive or cryptic/negative cats.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Survival probability was significantly lower for high positive cats than for low positive or cryptic/negative cats ( P <0.0001)",
      "review_status": "PASSED"
    },
    {
      "statement": "The study could not determine end-of-life viral load or cause of death because additional FeLV testing and necropsies were unavailable.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Another limitation was the inability to perform additional FeLV testing or necropsies at the time of death to determine viral load at the end of life or the cause of death.",
      "review_status": "PASSED"
    },
    {
      "statement": "Whether low positive cats that died had transitioned to high positive status remains unresolved.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:30Z"
  }
}