{
  "slug": "exploring-the-link-between-viruses-and-cancer-in-companion-ani-37386451",
  "source": {
    "title": "Exploring the link between viruses and cancer in companion animals: a comprehensive and comparative analysis.",
    "journal": "Infectious agents and cancer",
    "year": 2023,
    "doi": "10.1186/s13027-023-00518-7",
    "pmid": "37386451",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The review reports that lymphoma occurs in 10–20% of progressive FeLV infections.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Lymphoma is the most common lymphoid malignancy associated to progressive infection by FeLV [ 45 ] and it is reported to occur in 10–20% of progressive infections [ 46 – 48 ].",
      "review_status": "PASSED"
    },
    {
      "statement": "The review describes FeLV-associated lymphomas as predominantly high-grade T-cell lymphomas.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "FeLV-associated lymphomas are mainly high grade, T-type lymphomas, while their anatomic localization is related to the age of the host.",
      "review_status": "PASSED"
    },
    {
      "statement": "The review reports that molecular analyses identified common integration sites near c-myc, flvi-1, flvi-2, fit-1, pim-1, and flit-1 in FeLV-associated lymphomas.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Molecular analyses demonstrated that the most common integration sites (CISs) in FeLV-associated lymphomas occur in the vicinity of six genes, namely c-myc, flvi-1, flvi-2, fit-1, pim-1, and flit-1 [ 53 , 54 , 57 – 61 ].",
      "review_status": "PASSED"
    },
    {
      "statement": "Whether FeLV U3 transcripts contribute to oncogenesis through transactivation remains a proposed mechanism in this review.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "99",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-11-02 11:20 UTC",
    "updated_iso": "2026-11-02T11:20:26Z"
  }
}