{
  "slug": "diversity-of-fecal-viromes-and-zoonotic-risk-assessment-in-cap-42108251",
  "source": {
    "title": "Diversity of fecal viromes and zoonotic risk assessment in captive wild felids using viral metagenomics.",
    "journal": "Scientific reports",
    "year": 2026,
    "doi": "10.1038/s41598-026-52077-7",
    "pmid": "42108251",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The authors attribute the eukaryotic metabolic pathways dominating the RNA dataset to co-extracted host mRNA rather than direct viral manipulation of host metabolism.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "Conversely, the eukaryotic pathways dominating the RNA dataset (such as energy and arachidonic acid metabolism) simply stem from host mRNA co-extracted during our total nucleic acid protocol. Rather than indicating any direct viral manipulation of host metabolism, these signals reflect the typical shedding of feline epithelial and immune cells into the gut lumen 24 – 26 .",
      "review_status": "PASSED"
    },
    {
      "statement": "Whether the detected FeLV-homologous sequences represent latent FeLV infection remains unresolved.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}