{
  "slug": "development-of-a-new-feline-combination-vaccine-including-a-no-42506662",
  "source": {
    "title": "Development of a New Feline Combination Vaccine Including a Novel RNA Particle Vaccine Against Feline Leukemia Virus.",
    "journal": "Vaccines",
    "year": 2026,
    "doi": "10.3390/vaccines14070625",
    "pmid": "42506662",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The FeLV challenge studies did not use immunosuppressants before or during challenge.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "B",
      "confidence": "100",
      "evidence_excerpt": "No immunosuppressants were used in preparation for or during challenge procedures.",
      "review_status": "PASSED"
    },
    {
      "statement": "FeLV serology was not performed in the laboratory efficacy studies described in the serological-results section.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "B",
      "confidence": "100",
      "evidence_excerpt": "Serological responses against the FHV, FCV, and FPL components were analyzed during all OOI, 1-year and 3-year DOI efficacy studies. Serology for FeLV was not performed.",
      "review_status": "PASSED"
    },
    {
      "statement": "The immune mechanisms and correlates underlying protection for vaccine components other than FPL, including FeLV, remain unresolved.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-IMMUNOLOGY-002",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}