{
  "slug": "descriptive-assessment-of-cardiac-changes-in-cats-with-feline-42139320",
  "source": {
    "title": "Descriptive assessment of cardiac changes in cats with feline infectious peritonitis.",
    "journal": "Journal of veterinary internal medicine",
    "year": 2026,
    "doi": "10.1093/jvimsj/aalag083",
    "pmid": "42139320",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "Left ventricular posterior wall thickening was observed in a subset of cats with FIP.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "99",
      "evidence_excerpt": "The left ventricular posterior wall from right parasternal long axis and short axis was thickened in 55% (11/20) and 25% (5/20) of cats, respectively.",
      "review_status": "PASSED"
    },
    {
      "statement": "Pleural and pericardial effusions were observed in some cats, but the study did not identify a cardiac cause for those effusions.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "99",
      "evidence_excerpt": "Pleural effusion was present in 40% (8/20) of cats and pericardial effusion in 25% (5/20) of cats, but a cardiac cause was not identified for these effusions.",
      "review_status": "PASSED"
    },
    {
      "statement": "Median cTnI at initial evaluation was above the reported upper reference interval in cats with FIP.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "98",
      "evidence_excerpt": "Median cTnI at initial evaluation was 0.37 ng/ml (interquartile range [IQR], 0.20-0.83; upper reference interval, 0.20 ng/ml).",
      "review_status": "PASSED"
    },
    {
      "statement": "In six cats with initially increased cTnI, cTnI normalized after 12 weeks of antiviral treatment.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "99",
      "evidence_excerpt": "Repeat cTnI was performed after 12 weeks of antiviral treatment in 6 cats that initially had increased cTnI (median initial cTnI, 0.75 ng/mL) and, in all 6 cats, cTnI normalized to < 0.20 ng/mL.",
      "review_status": "NEEDS_HUMAN"
    },
    {
      "statement": "The study prospectively assessed cardiac changes in twenty cats with naturally occurring FIP and no previous history of heart disease.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "98",
      "evidence_excerpt": "ANIMALS: Twenty cats with naturally occurring FIP without previous history of heart disease.",
      "review_status": "PASSED"
    },
    {
      "statement": "Cats diagnosed with FIP were tested for feline leukemia virus antigen as part of screening for concurrent infections associated with myocarditis.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "98",
      "evidence_excerpt": "Cats diagnosed with FIP were tested for common concurrent infections associated with myocarditis by testing serum for feline immunodeficiency virus (FIV) antibodies, feline leukemia virus antigen (FeLV), Dirofilaria immitis antigen, Bartonella spp. immunoglobulin G (IgG), and Toxoplasma gondii IgG and immunoglobulin M (IgM) as well as by testing blood for nucleic acids of Bartonella spp. and coronavirus (SARS-COV-2).",
      "review_status": "PASSED"
    },
    {
      "statement": "The authors conclude that cats with FIP can present with increased cTnI and ventricular wall thickening suggestive of myocarditis or myocardial injury.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "99",
      "evidence_excerpt": "Cats with FIP can present with increases in cTnI and ventricular wall thickening, findings suggestive of myocarditis or myocardial injury.",
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-VIROLOGY-001",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-08-31 19:44 UTC",
    "updated_iso": "2026-08-31T19:44:44Z"
  }
}