{
  "slug": "cross-species-transmission-of-host-adaptation-of-feline-leukem-42288833",
  "source": {
    "title": "Cross-species transmission of host adaptation of feline leukemia virus between domestic cats and the wild felid Leopardus guigna.",
    "journal": "Veterinary research",
    "year": 2026,
    "doi": "10.1186/s13567-026-01770-6",
    "pmid": "42288833",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The discussion reports that Gly109Arg had previously been described in domestic cats with tumors.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "For instance, the Gly109Arg substitution was originally described in domestic cats with tumors [ 64 ].",
      "review_status": "PASSED"
    },
    {
      "statement": "Guigna FeLV sequences formed a phylogenetic cluster with greater than 90% bootstrap support adjacent to the Chilean domestic-cat cluster.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "Guigna samples clustered together in a robust phylogenetic separation (>90% of bootstrap support), without distinction between FeLV-A and FeLV-B amplicons (Figure 2 ). This guigna clade is adjacent to the cluster of Chilean domestic cats (Figure 2 and Additional file 1 ) and was positioned near a puma sequence from the USA.",
      "review_status": "PASSED"
    },
    {
      "statement": "Sequenced amplicons produced with FeLV-B-specific primers contained FeLV-A sequences rather than confirming FeLV-B infection.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "Although FeLV-B specific primers yielded amplicons, they revealed only FeLV-A sequences with random nucleotides attached to the 5′ end.",
      "review_status": "PASSED"
    },
    {
      "statement": "The functional significance of the discussed serine substitution in the receptor-interaction region remains unknown.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    },
    {
      "statement": "Whether guigna APOBEC3 causes the observed FeLV hypermutation pattern remains unresolved.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:30Z"
  }
}