{
  "slug": "comparative-measurement-of-felv-load-in-hemolymphatic-tissues-31856815",
  "source": {
    "title": "Comparative measurement of FeLV load in hemolymphatic tissues of cats with hematologic cytopenias.",
    "journal": "BMC veterinary research",
    "year": 2019,
    "doi": "10.1186/s12917-019-2208-y",
    "pmid": "31856815",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "Viral RNA was significantly more abundant in the spleen than in whole blood and bone marrow in these cats.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "90",
      "evidence_excerpt": "We detected a significantly greater number of viral RNA in the spleen compared with the whole blood and bone marrow.",
      "review_status": "PASSED"
    },
    {
      "statement": "In 31 cats with FeLV-associated clinical signs and at least one hematologic cytopenia, FeLV RNA was detected by RT-qPCR in all cats, whereas 24 of 31 were positive for serum FeLV antigen.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "90",
      "evidence_excerpt": "Viral RNA copy numbers were detected in all cats by RT-qPCR whereas 24 out of 31 cats were positive for the serum FeLV antigen.",
      "review_status": "PASSED"
    },
    {
      "statement": "Bone marrow contained detectable FeLV RNA in cytopenic cats, but at a lower level than spleen. This is compatible with marrow involvement in FeLV-associated cytopenias but does not show that viral load in marrow causes the cytopenias.",
      "epistemic_type": "INFERENCE",
      "evidence_level": null,
      "confidence": "55",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    },
    {
      "statement": "It is unknown whether FeLV RNA load in bone marrow, spleen or blood relates to the specific type or severity of cytopenia (anemia, thrombocytopenia, neutropenia, pancytopenia).",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "60",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-HEMATOLOGY-003",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "sonnet",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:30Z"
  }
}