{
  "slug": "chronic-atypical-myelomonocytic-leukemia-of-eosinophilic-linea-41768374",
  "source": {
    "title": "Chronic Atypical Myelomonocytic Leukemia of Eosinophilic Lineage in a Cat With Feline Leukemia Virus: A First Case Report.",
    "journal": "Case reports in veterinary medicine",
    "year": 2026,
    "doi": "10.1155/crve/6729159",
    "pmid": "41768374",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The authors diagnosed atypical CMML of eosinophilic lineage from bone marrow examination and peripheral blood studies.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Based on the findings obtained from bone marrow examination along with peripheral blood studies, a diagnosis of atypical CMML of the eosinophilic lineage is concluded.",
      "review_status": "PASSED"
    },
    {
      "statement": "The authors reported diffuse alpha-naphthyl acetate esterase positivity in 21.3% of cells that appeared morphologically compatible with myeloid/neutrophilic lineage.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Then, 21.3% of cells that were morphologically compatible with myeloid/neutrophilic lineage were positive in a diffuse pattern to alpha‐naphthyl acetate esterase.",
      "review_status": "PASSED"
    },
    {
      "statement": "Morphologically eosinophilic cells constituted 45.4% of medullary cells and were negative for both myeloperoxidase and alpha-naphthyl acetate esterase.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Atypical observation includes 45.4% of medullary cells belonging to the eosinophilic lineage (morphologically), which are negative for myeloperoxidase and alpha‐naphthyl acetate esterase by enzymatic cytochemical methods.",
      "review_status": "PASSED"
    },
    {
      "statement": "The authors considered the case atypical because hypereosinophilia in blood and marrow prevented it from fitting classic WHO criteria.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "It should be emphasized that in this specific case, hypereosinophilia was observed in both blood and marrow, which causes this patient′s classification to not fit the classic WHO criteria and should be considered atypical.",
      "review_status": "PASSED"
    },
    {
      "statement": "Karyotyping was not performed because the cat died 2 days after diagnosis.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "In this case, karyotyping was not possible because the patient died 2 days after diagnosis.",
      "review_status": "PASSED"
    },
    {
      "statement": "This case does not establish that FeLV caused the reported leukemia.",
      "epistemic_type": "INFERENCE",
      "evidence_level": null,
      "confidence": "98",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}