{
  "slug": "an-exceptional-case-of-peritoneal-cystic-echinococcosis-in-a-d-39957497",
  "source": {
    "title": "An exceptional case of peritoneal cystic echinococcosis in a domestic cat in Australia.",
    "journal": "Australian veterinary journal",
    "year": 2025,
    "doi": "10.1111/avj.13427",
    "pmid": "39957497",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "Liver and spleen samples from the cat tested positive for FeLV and negative for FIV by nested PCR.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Both liver and spleen samples showed positive results in nested PCRs for FeLV and negative for FIV.",
      "review_status": "PASSED"
    },
    {
      "statement": "Histology showed fibrosis and macrophage, multinucleated giant cell, lymphocyte, and plasma cell infiltrates surrounding embedded cysts.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Frequently concentrically surrounding cysts and further expanding the peritoneum were concentric, laminated layers of parallel, eosinophilic, fibrillar matrix embedded with numerous fibroblasts (fibrosis) surrounded and embedded with expanded epithelioid macrophages and multinucleated giant cells as well as large, dense clusters of lymphocytes and plasma cells and occasionally multifocal aggregates of extravasated erythrocytes (haemorrhage).",
      "review_status": "PASSED"
    },
    {
      "statement": "Sequencing identified E. granulosus sensu stricto genotype G1 in the positive parasite PCR product.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Sequencing the positive PCR product showed the E. granulosus s.s genotype G1 with 99.36 identity to Australian isolates.",
      "review_status": "PASSED"
    },
    {
      "statement": "FeLV-associated immunosuppression may have contributed to CE development in this cat.",
      "epistemic_type": "INFERENCE",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    },
    {
      "statement": "Whether the hepatic cyst led to secondary peritoneal cysts through leakage of protoscoleces remains unknown.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-IMMUNOLOGY-002",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "gpt-6.1-sol",
    "updated": "2026-11-02 11:20 UTC",
    "updated_iso": "2026-11-02T11:20:25Z"
  }
}