{
  "slug": "adaptation-of-lentiviral-vectors-for-viral-gene-therapy-and-th-41593679",
  "source": {
    "title": "Adaptation of lentiviral vectors for viral gene therapy and their impact on host cell biology.",
    "journal": "Journal of translational medicine",
    "year": 2026,
    "doi": "10.1186/s12967-025-07626-5",
    "pmid": "41593679",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "Vector copy number, measured by quantitative PCR, is the current standard clinical measure of LVV-modified cell engraftment but does not determine integration site location or clonality.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "85",
      "evidence_excerpt": "VCN is performed using quantitative polymerase chain reaction (PCR) [ 95 – 99 ] and does not determine integration site location or clonality [ 100 ].",
      "review_status": "PASSED"
    },
    {
      "statement": "The effect of LVV integration on host RNA regulation and splicing, and its link to clinical outcomes and long-term vector safety, remains incompletely understood.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "80",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-VIROLOGY-001",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "sonnet",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}