{
  "slug": "a-retrospective-investigation-of-28-cats-with-intermediate-to-41897966",
  "source": {
    "title": "A Retrospective Investigation of 28 Cats with Intermediate- to Large-Cell Lymphoma Treated with Lomustine and Prednisolone as a First-Line Chemotherapy.",
    "journal": "Animals : an open access journal from MDPI",
    "year": 2026,
    "doi": "10.3390/ani16060989",
    "pmid": "41897966",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "The study did not determine lymphoma immunophenotype, preventing analysis of T-cell versus B-cell response differences.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Additionally, immunophenotypic classification of lymphoma cells into T-cell or B-cell lineages was not performed, precluding analysis of lineage-specific treatment responses.",
      "review_status": "PASSED"
    },
    {
      "statement": "All 28 cats in the study tested negative for FeLV.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "In contrast, all 28 cats in our study tested negative for FeLV, and the alimentary form was predominant, accounting for 75.0% of the cases, whereas mediastinal lymphoma was observed in only 3.6% of cats.",
      "review_status": "PASSED"
    },
    {
      "statement": "The authors identify substantial early censoring as a limitation of survival-outcome interpretation.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "C",
      "confidence": "100",
      "evidence_excerpt": "Interpretation of survival outcomes in this study is limited by a substantial early-censoring pattern. Most censored cases occurred during the early follow-up period, whereas death events were relatively sparse and tended to occur later. This distribution of events may have precluded estimation of the MST using Kaplan–Meier analysis.",
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-ONCOLOGY-004",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}