{
  "slug": "a-naturally-occurring-feline-leukaemia-virus-subgroup-a-varian-42809448",
  "source": {
    "title": "A naturally occurring feline leukaemia virus subgroup A variant exhibits broad mammalian cellular tropism and utilizes canine thiamine transporter 1.",
    "journal": "The Journal of general virology",
    "year": 2026,
    "doi": "10.1099/jgv.0.002316",
    "pmid": "42809448",
    "content_access_status": "FULL_TEXT_OA"
  },
  "claims": [
    {
      "statement": "Clone-derived F8701 was replication-competent in feline cells and grew comparably to established FeLV-A strains.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "These results indicate that clone-derived F8701 is replication-competent in feline cells and grows comparably to established FeLV-A strains.",
      "review_status": "PASSED"
    },
    {
      "statement": "F8701 Env mediated greater pseudotype infectivity than Glasgow-1 Env in several non-feline mammalian cell lines.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "Compared with Glasgow-1 Env, F8701 Env yielded markedly higher titres in several non-feline mammalian cell lines.",
      "review_status": "PASSED"
    },
    {
      "statement": "F8701 retained the FeLV-A interference subgroup phenotype despite its broadened cellular host range.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "This interference pattern indicates that F8701 uses the FeLV-A entry pathway and belongs to interference subgroup A, despite its broadened cellular host range.",
      "review_status": "PASSED"
    },
    {
      "statement": "F8701 underwent productive replication in cultured canine D17 cells more efficiently than the reference FeLV-A strains tested.",
      "epistemic_type": "EVIDENCE",
      "evidence_level": "D",
      "confidence": "100",
      "evidence_excerpt": "These results indicate that F8701 can undergo productive replication in cultured canine D17 cells more efficiently than the reference FeLV-A strains tested.",
      "review_status": "PASSED"
    },
    {
      "statement": "Whether the Env 105 N residue causally contributes to F8701's broad cellular tropism remains unresolved.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    },
    {
      "statement": "Whether F8701 can establish productive infection or transmission in dogs in vivo remains unknown.",
      "epistemic_type": "OPEN_QUESTION",
      "evidence_level": null,
      "confidence": "100",
      "evidence_excerpt": null,
      "review_status": "PASSED"
    }
  ],
  "provenance": {
    "agent": "AVAPROJECT-VIROLOGY-001",
    "critic": "AVAPROJECT-CRITIC-001",
    "model": "openai-codex",
    "updated": "2026-10-31 11:30 UTC",
    "updated_iso": "2026-10-31T11:30:31Z"
  }
}